Difficult to Treat Psychosis

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Course information
This course will be taking place online
Course information
This course will be taking place online
About the course

This one-day course provides a best-practice update on treatment-resistant psychosis and clozapine non-responsive schizophrenia. It is delivered by the multidisciplinary team from the National Psychosis Unit (NPU).

Most general psychiatrists in the UK provide care to people with a range of psychotic disorders. Although more people with a single episode of psychosis recover than was previously thought, 23% of people with their first episode of psychosis do not respond to medications from the start and overall a third of people with schizophrenia do not respond to two courses of standard anti-psychotics.

In those circumstances clozapine is indicated as it is the only evidenced-based treatment for treatment resistant schizophrenia.

However, there are sometimes problems with tolerability of clozapine. Also, many people do not achieve a full response to clozapine treatment, and there is limited evidence for next steps.

Course programme

The course will include updates on evidence-based pharmacological and psychological management of 'resistant' psychosis, an update on clinical genomics in psychosis, as well as talks on research to inform future approaches. The day will end with a panel discussion where there will be the opportunity to discuss clinical management strategies with the team.

The NPU works to facilitate the safe introduction of evidence into clinical practice in a bespoke individualized fashion, with a particular emphasis on innovative approaches and physical health.

Learning objectives

After attending this course, participants will be able:

  • Summarise the evidence for pharmacological strategies in “resistant” psychosis
  • Know how to improve the tolerability of clozapine
  • Understand the psychological strategies used in the management of people with psychosis
  • Appreciate the potential and limitations of biomarkers in informing management of psychosis
  • Understand the potential for clinical genomics in understanding and managing psychosis

Course schedule

Target audience
Psychiatrists including trainees
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