Difficult to Treat Psychosis

Mental healthcare

Course information

Upcoming Date: TBC
Upcoming Time: TBC
Length: 1 day
Cost: Free
Equivalent to 6 CPD hours

About the course

Difficult to Treat Psychosis

Most general psychiatrists in the UK provide care to people with a range of psychotic disorders. Although more people with a single episode of psychosis recover than was previously thought, 23% of people with their first episode of psychosis do not respond to medications from the start and overall a third of people with schizophrenia do not respond to two courses of standard anti-psychotics. In those circumstances clozapine is indicated as it is the only evidenced-based treatment for treatment resistant schizophrenia.  

However, there are sometimes problems with tolerability of clozapine. Additionally, many people do not achieve a full response to clozapine treatment, and there is limited evidence for next steps.  

This training programme will provide a best-practice update on treatment resistant psychosis, including treatment-resistant and clozapine non-responsive schizophrenia. It is deliveed by the multidisciplinary team from the National Psychosis Unit (NPU). The NPU works to facilitate the safe introduction of evidence into clinical practice in a bespoke individualized fashion, with a particular emphasis on innovative approaches and physical health.  

The course will include updates on evidence-based pharmacological and psychological management of “resistant” psychosis, an update on clinical genomics in psychosis, as well as talks on research to inform future approaches. The day will end with a panel discussion where there will be the opportunity to discuss clinical management strategies with the team.  






A group of people standing in a circle with their hands in the middle.

Learning Objectives

After attending this course, participants will be able:

  • Summarise the evidence for pharmacological strategies in “resistant” psychosis
  • Know how to improve the tolerability of clozapine
  • Understand the psychological strategies used in the management of people with psychosis
  • Appreciate the potential and limitations of biomarkers in informing management of psychosis
  • Understand the potential for clinical genomics in understanding and managing psychosis

Course Information

Target audience

Academic, Consultant – psychiatry, CT1-3 – psychiatry, ST4-7 – psychiatry

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